Pseudallescheria boydii arthritis and osteomyelitis in a patient with Cushing's disease

South Med J. 1987 Jan;80(1):90-2. doi: 10.1097/00007611-198701000-00020.

Abstract

Pseudallescheria boydii infection involving the left distal femur and knee joint developed in a patient with Cushing's disease, and recurred after treatment with both intravenous miconazole and intravenous amphotericin B. The patient subsequently had synovectomy and arthrodesis, and received ketoconazole, 600 mg per day orally for one year. Concurrent with the start of ketoconazole, a bilateral adrenalectomy was done to control endogenous hypercortisolism. The patient's infection then resolved, and one year afterward there is no clinical or radiologic evidence of recurrent infection.

Publication types

  • Case Reports

MeSH terms

  • Adrenalectomy
  • Arthritis, Infectious / complications*
  • Arthritis, Infectious / therapy
  • Combined Modality Therapy
  • Cushing Syndrome / complications*
  • Humans
  • Ketoconazole / therapeutic use
  • Knee Joint / microbiology
  • Male
  • Miconazole / therapeutic use
  • Middle Aged
  • Mycetoma / complications*
  • Mycetoma / diagnosis
  • Mycetoma / therapy
  • Osteomyelitis / complications*
  • Osteomyelitis / therapy
  • Pseudallescheria / isolation & purification
  • Recurrence

Substances

  • Miconazole
  • Ketoconazole