Baseline and longitudinal cardiovascular health using Life's Essential 8 metrics with the risk of incident hypertension

Clin Exp Hypertens. 2023 Dec 31;45(1):2271190. doi: 10.1080/10641963.2023.2271190. Epub 2023 Nov 20.


Objective: The quantification of cardiovascular health (CVH) was updated by the American Heart Association recently by using the "Life's Essential 8" (LE8) score. We aimed to investigate the associations of baseline and longitudinal CVH status measured by the new LE8 score (except for blood pressure) with the risk of hypertension.

Methods: A total of 52 990 participants with complete data on LE8 metrics and without hypertension were enrolled from the Kailuan study, Tangshan, China. The associations of incident hypertension with the overall baseline, time-updated, and time-varying CVH score (ranging 0 [lowest] to 100 [highest]), and each component of LE8, were assessed by Cox regressions.

Results: During a median follow-up of 10.73 years 28 380 cases of incident hypertension were identified. The risk of hypertension attenuated with increased CVH score (Ptrend < 0.0001), the hazard ratios (HRs) in high CVH versus low CVH group was 0.54 (95% confidence interval [CI], 0.51-0.57) for baseline CVH, 0.47 (95% CI, 0.45-0.50) for time-updated CVH, and 0.59 (95% CI, 0.55-0.63) for time-varying CVH. The predictive value of CVH in predicting hypertension improved by using LE8 than using Life's Simple 7 metrics. Among LE8 components, body mass index score was the strongest risk factor for hypertension. Subgroup analyses showed that the benefit of a higher CVH score on hypertension was more prominent in young adults and in women (Pinteraction < 0.05).

Conclusions: A higher CVH score assessed by new LE8 is associated with a lower risk of subsequent hypertension, especially young adults and women.

Keywords: Life’s Essential 8; cardiovascular health; cohort study; hypertension; longitudinal association.

MeSH terms

  • Blood Pressure
  • Cardiovascular Diseases* / epidemiology
  • Cardiovascular Diseases* / etiology
  • Female
  • Humans
  • Hypertension* / epidemiology
  • Incidence
  • Risk Factors
  • United States
  • Young Adult