Diplomyelia: caudal duplication of the neural tube in mice

Teratology. 1986 Dec;34(3):343-52. doi: 10.1002/tera.1420340314.


Diplomyelia (duplication of the neural tube or spinal cord) was studied histologically in nine cases of T/+ mouse embryos at 10-15 days of gestation. Grüneberg investigated T/+ fetuses and interpreted the extra neural tube to be notochord, but a reexamination of this material demonstrated that the interpretation is incorrect. Diplomyelia is produced in the mutations Fused, Kinky, vestigial tail, homozygous Brachyury, and t-haplotype t9 and in the new mutation, NM 529, described here.

MeSH terms

  • Animals
  • Gestational Age
  • Heterozygote
  • Homozygote
  • Mice
  • Mice, Mutant Strains
  • Neural Tube Defects / embryology*
  • Neural Tube Defects / genetics
  • Neural Tube Defects / pathology
  • Notochord / pathology
  • Phenotype
  • Tail / abnormalities