ARFID Genes and Environment (ARFID-GEN): study protocol

BMC Psychiatry. 2023 Nov 21;23(1):863. doi: 10.1186/s12888-023-05266-x.


Background: The Avoidant Restrictive Food Intake Disorder - Genes and Environment (ARFID-GEN) study is a study of genetic and environmental factors that contribute to risk for developing ARFID in children and adults.

Methods: A total of 3,000 children and adults with ARFID from the United States will be included. Parents/guardians and their children with ARFID (ages 7 to 17) and adults with ARFID (ages 18 +) will complete comprehensive online consent, parent verification of child assent (when applicable), and phenotyping. Enrolled participants with ARFID will submit a saliva sample for genotyping. A genome-wide association study of ARFID will be conducted.

Discussion: ARFID-GEN, a large-scale genetic study of ARFID, is designed to rapidly advance the study of the genetics of eating disorders. We will explicate the genetic architecture of ARFID relative to other eating disorders and to other psychiatric, neurodevelopmental, and metabolic disorders and traits. Our goal is for ARFID to deliver "actionable" findings that can be transformed into clinically meaningful insights.

Trial registration: ARFID-GEN is a registered clinical trial: NCT05605067.

Keywords: Avoidant restrictive food intake disorder; Eating disorders; Genome-wide association; Picky eating; Psychiatric genetics; Psychiatric genomics consortium; Selective eating; Social media.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Avoidant Restrictive Food Intake Disorder*
  • Child
  • Feeding and Eating Disorders*
  • Genome-Wide Association Study
  • Humans
  • Motivation
  • Retrospective Studies

Associated data