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Found 1 result for JAT210475/the Education Scientific Research Project of Young Teachers of Fujian Province[Grants and Funding]
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. 2023 Nov 22;23(1):461.
doi: 10.1186/s12890-023-02762-4.

Tea consumption and risk of lung diseases: a two‑sample Mendelian randomization study

Linjie Chen  1   2   3 , Yaru Deng  1   2 , Tiexu Wang  1   2 , Xinyu Lin  1   2 , Lukun Zheng  1   2 , Xiaohong Chen  4   5 , Tongsheng Chen  6   7   8
Affiliations

Tea consumption and risk of lung diseases: a two‑sample Mendelian randomization study

Linjie Chen et al. BMC Pulm Med. .

Abstract

Background: Numerous studies have reported the association between tea intake and lung diseases. However, the probable relationship between tea consumption on lung diseases still remain controversial and it is unclear whether these findings are due to reverse causality or confounding factor.

Methods: In order to systematically investigate the causal connection between tea intake on respiratory system disorders, we employed a two-sample Mendelian randomized (MR) study. Genetic instruments for tea intake were identified from a genome-wide association study (GWAS) involving 447,385 individuals. Data on lung diseases were collected from a variety of publicly available genome-wide association studies. The main method used for MR analysis is the inverse variance weighting (IVW) method. To ensure the accuracy of the findings, further sensitivity analysis was conducted.

Results: The IVW method in our MR analysis revealed no evidence to support a causal relationship between tea intake and lung diseases (IPF: OR = 0.997, 95% CI = 0.994-1.000, p = 0.065; Lung cancer: OR = 1.003, 95% CI = 0.998-1.008, P = 0.261; COPD: OR = 1.001, 95% CI = 0.993-1.006, p = 0.552; acute bronchitis: OR = 0.919, 95% CI = 0.536-1.576, p = 0.759; tuberculosis: OR = 1.002, 95% CI = 0.998-1.008, p = 0.301; pneumonia: OR = 0.789, 95% CI = 0.583-1.068, p = 0.125). The reliability of the results was further demonstrated by four additional MR analysis techniques and additional sensitivity testing.

Conclusion: We found no evidence of a link between tea intake on lung diseases in our MR results based on genetic information.

Keywords: COPD; IPF; Lung cancer; Lung diseases; Mendelian randomization; Tea consumption.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Design of Mendelian randomization study of tea intake and lung diseases The instrumental variable in this Mendelian randomization study was based on the hypothesis that it was related to tea intake but not to confounding variables, and that it only impacted the risk of six lung diseases through tea intake
Fig. 2
Fig. 2
Forest plot showed the causal association between tea intake and lung disease. (A) IPF; (B) lung cancer; (C) COPD; (D) acute bronchitis; (E) tuberculosis; (F) pneumonia. OR, odds ratio; 95% CI, 95% confidence interval; IPF, idiopathic pulmonary fibrosis; COPD, chronic obstructive pulmonary diseases
Fig. 3
Fig. 3
MR leave-one-out sensitivity analysis of tea intake on lung disease. Circles indicate the results of MR analysis of remaining SNPs on tea intake on lung disease after omitting each SNP in turn. Bars indicate CI. (A) IPF; (B) lung cancer; (C) COPD; (D) acute bronchitis; (E) tuberculosis; (F) pneumonia
Fig. 4
Fig. 4
Estimating heterogeneity using funnel plots of individual causal relationships between tea intake and lung disease. (A) IPF; (B) lung cancer; (C) COPD; (D) acute bronchitis; (E) tuberculosis; (F) pneumonia
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