Microcatheter-Directed Thrombolysis Using Recombinant Tissue Plasminogen Activator for the Treatment of Acute Superior Mesenteric Artery Embolism: A Case Report

Medicina (Kaunas). 2023 Oct 24;59(11):1889. doi: 10.3390/medicina59111889.

Abstract

Background: Acute mesenteric ischemia (AMI) is a life-threatening condition, and in 50% of patients, AMI is caused by acute superior mesenteric artery (SMA) embolism. Endovascular treatment is increasingly being considered the primary modality in selected cases. Many studies have reported that percutaneous aspiration embolectomy using a guiding catheter and thrombolysis with recombinant tissue plasminogen activator (rtPA) are effective in treating SMA embolism. However, no reports on treating SMA embolism using rtPA administered via a microcatheter exist. Case presentation: A 64-year-old man with underlying atrial fibrillation presented with acute SMA embolism revealed using computed tomography (CT). rtPA (total 3 mg) was carefully administered into the occluded SMA through a microcatheter. No complications occurred, and complete revascularization of the SMA was revealed on follow-up CT. Conclusions: Compared with previous reports, this case report reveals that successful revascularization can be achieved using rtPA administered via a microcatheter, with a low dose of rtPA and a short duration of thrombolysis.

Keywords: acute mesenteric ischemia; embolectomy; endovascular treatment; revascularization; superior mesenteric artery; thrombolysis.

Publication types

  • Case Reports

MeSH terms

  • Embolism* / complications
  • Embolism* / drug therapy
  • Gastrointestinal Diseases* / complications
  • Humans
  • Male
  • Mesenteric Artery, Superior
  • Mesenteric Ischemia* / complications
  • Mesenteric Ischemia* / therapy
  • Mesenteric Vascular Occlusion* / etiology
  • Mesenteric Vascular Occlusion* / therapy
  • Middle Aged
  • Thrombolytic Therapy / methods
  • Tissue Plasminogen Activator / therapeutic use
  • Treatment Outcome

Substances

  • Tissue Plasminogen Activator

Grants and funding

This research received no external funding.