Locally Advanced Adenoid Cystic Carcinoma of the Breast-A Case Report with a Review of the Literature

Medicina (Kaunas). 2023 Nov 15;59(11):2005. doi: 10.3390/medicina59112005.


Breast cancer (BC) is a heterogeneous disease distinguished by four main subtypes based on the expression of estrogen, progesterone receptors, and human epidermal growth factor-2 on the cancer cells. Triple-negative breast cancer (TNBC) consists of approximately 10-20% of all BCs and is characterized by a poor prognosis. Adenoid cystic carcinoma (ACC) of the breast is a rare, special type of TNBC with low metastatic potential and usually favorable prognosis. There are no established recommendations concerning systemic therapy in advanced ACC. We present a case of a 70-year-old woman with locally advanced ACC with progression after radical mastectomy, and review the literature concerning the treatment of metastatic disease focused on systemic therapy.

Keywords: adenoid cystic carcinoma; metastasis; systemic therapy; triple-negative breast cancer.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Aged
  • Breast
  • Breast Neoplasms* / pathology
  • Carcinoma, Adenoid Cystic* / metabolism
  • Carcinoma, Adenoid Cystic* / pathology
  • Carcinoma, Adenoid Cystic* / surgery
  • Female
  • Humans
  • Mastectomy
  • Prognosis
  • Triple Negative Breast Neoplasms*

Grants and funding

This research received no external funding. Publication cost was covered by the Medical University of Silesia in Katowice.