Vascular risk factors and leuko-araiosis

Arch Neurol. 1987 Jan;44(1):42-7. doi: 10.1001/archneur.1987.00520130034014.


Leuko-araiosis was found in 49 of 140 demented patients compared with 12 out of 110 control subjects. Thirty-one of 95 patients with dementia of the Alzheimer's type had leuko-araiosis. A history of stroke was four times more frequent in patients with leuko-araiosis than in those without leuko-araiosis (17.4% and 4.4%, respectively). It occurred in 25% of controls with leuko-araiosis compared with only 2% of those without leuko-araiosis. Mean systolic blood pressure was associated with leuko-araiosis. No association was found for diastolic blood pressure, myocardial infarction, angina, diabetes, or carotid bruits. On logistic regression analysis, the strong association between dementia and leuko-araiosis was mainly explained by a history of stroke. There are common factors in leuko-araiosis and stroke, but stroke alone does not account for leuko-araiosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aging / pathology
  • Brain / diagnostic imaging
  • Brain / pathology*
  • Cerebrovascular Disorders / complications*
  • Cerebrovascular Disorders / pathology
  • Dementia / pathology*
  • Female
  • Humans
  • Hypertension / pathology
  • Male
  • Myelin Sheath / pathology*
  • Tomography, X-Ray Computed