Myocardial infarction complexity: A multi-omics approach

Clin Chim Acta. 2024 Jan 1:552:117680. doi: 10.1016/j.cca.2023.117680. Epub 2023 Nov 25.


Myocardial infarction (MI), a prevalent cardiovascular disease, is fundamentally precipitated by thrombus formation in the coronary arteries, which subsequently decreases myocardial perfusion and leads to cellular necrosis. The intricacy of MI pathogenesis necessitates extensive research to elucidate the disease's root cause, thereby addressing the limitations present in its diagnosis and prognosis. With the continuous advancement of genomics technology, genomics, proteomics, metabolomics and transcriptomics are widely used in the study of MI, which provides an excellent way to identify new biomarkers that elucidate the complex mechanisms of MI. This paper provides a detailed review of various genomics studies of MI, including genomics, proteomics, transcriptomics, metabolomics and multi-omics studies. The metabolites and proteins involved in the pathogenesis of MI are investigated through integrated protein-protein interactions and multi-omics analysis by STRING and Metascape platforms. In conclusion, the future of omics research in myocardial infarction offers significant promise.

Keywords: Biomarker; Multi-omics; Myocardial infarction; Pathway.

Publication types

  • Review

MeSH terms

  • Genomics
  • Humans
  • Metabolomics
  • Multiomics*
  • Myocardial Infarction* / diagnosis
  • Myocardial Infarction* / genetics
  • Proteomics