Oral administration of hyaluronic acid to improve skin conditions via a randomized double-blind clinical test

Skin Res Technol. 2023 Nov;29(11):e13531. doi: 10.1111/srt.13531.


Objective: To evaluate the impact of oral intake of Hyaluronic Acid (HA) on skin health.

Background: HA, an endogenous substance in the human body, plays a key role in skin health. However, its concentration in the skin decreases significantly with age. Previous studies suggested that oral intake of HA can supplement the body's HA level, but did not reveal the effects on different age groups and skin types.

Methods: A double-blind, randomized clinical trial with 129 female participants, covering young and elderly groups and differnet skin types, was conducted to assess the efficacy of orally administered HA on skin health.

Results: Oral administration of HA significantly promoted skin hydration after 2-8 weeks among both young and elderly groups. Skin tone improvement was observed after 4-8 weeks, while an increase in epidermal thickness was noted after 12 weeks.

Conclusion: This study provides direct evidence supporting the clinical efficacy of oral intake of HA in promoting skin health.

Keywords: clinical benefit; hyaluronan; hyaluronic acid; oral administration; skin health.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Aged
  • Double-Blind Method
  • Epidermis
  • Female
  • Humans
  • Hyaluronic Acid*
  • Skin
  • Skin Diseases*


  • Hyaluronic Acid