Immune checkpoint inhibitor-induced lichenoid drug eruption-sparing scar burns

Australas J Dermatol. 2023 Nov 27. doi: 10.1111/ajd.14192. Online ahead of print.

Abstract

The authors present a striking case of a patient experiencing a lichenoid drug eruption secondary to immunotherapy, curiously sparing scarred skin from past burns. We observed vastly higher amounts of inflammatory lymphoid cells staining for PD-1; 70% in skin with a lichenoid drug reaction and 50% in scarred skin. The lack of a lichenoid reaction at sites of scarred skin may indicate that a basement membrane component may be causative for a lichenoid drug eruption.

Keywords: PD-1 inhibitor; immune-related adverse events; immunotherapy; lichenoid eruption; melanoma.