Abstract
We have previously reported that male DBA/1 mice are more susceptible to collagen-induced arthritis than are females. Here we report that oophorectomy makes female mice as susceptible to collagen arthritis as are normal males. Induction of collagen-induced arthritis in mice is a T cell-dependent process. The role of female sex hormones in modulating T cell-dependent autoimmune diseases is discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Arthritis / chemically induced*
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Autoantibodies / analysis
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Castration
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Collagen / antagonists & inhibitors*
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Collagen / classification
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Collagen / immunology
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Collagen / pharmacology
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Disease Susceptibility
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Female
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Genetic Linkage
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Gonadal Steroid Hormones / pharmacology*
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Male
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Mice
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Mice, Inbred Strains
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Sex Characteristics
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Sex Chromosomes / physiology
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Y Chromosome / physiology
Substances
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Autoantibodies
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Gonadal Steroid Hormones
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Collagen