Female sex hormones suppress development of collagen-induced arthritis in mice

Arthritis Rheum. 1986 Dec;29(12):1501-9. doi: 10.1002/art.1780291212.

Abstract

We have previously reported that male DBA/1 mice are more susceptible to collagen-induced arthritis than are females. Here we report that oophorectomy makes female mice as susceptible to collagen arthritis as are normal males. Induction of collagen-induced arthritis in mice is a T cell-dependent process. The role of female sex hormones in modulating T cell-dependent autoimmune diseases is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arthritis / chemically induced*
  • Autoantibodies / analysis
  • Castration
  • Collagen / antagonists & inhibitors*
  • Collagen / classification
  • Collagen / immunology
  • Collagen / pharmacology
  • Disease Susceptibility
  • Female
  • Genetic Linkage
  • Gonadal Steroid Hormones / pharmacology*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Sex Characteristics
  • Sex Chromosomes / physiology
  • Y Chromosome / physiology

Substances

  • Autoantibodies
  • Gonadal Steroid Hormones
  • Collagen