Adherence to Congestive Heart Failure Guidelines and Outcome in the Middle East

Raed Aqel; Tareq Alzughayyar; Jihad Zalloum; Qais Salah; Qutaiba Qafisheh; Mahmoud Izraiq

doi:10.2174/011573403X256576231017110252

Adherence to Congestive Heart Failure Guidelines and Outcome in the Middle East

Curr Cardiol Rev. 2023 Nov 23. doi: 10.2174/011573403X256576231017110252. Online ahead of print.

Authors

Raed Aqel¹, Tareq Alzughayyar², Jihad Zalloum³, Qais Salah³, Qutaiba Qafisheh², Mahmoud Izraiq⁴

Affiliations

¹ National Center for Diabetes, Endocrinology and Genetics, Amman, Jordan.
² College of Medicine and Health Sciences, Palestine Polytechnic University, Hebron, State of Palestine.
³ Faculty of Medicine, Al Quds University, Jerusalem, Palestine.
⁴ The Specialty Hospital, private sector, Amman, Jordan.

PMID: 38018202
DOI: 10.2174/011573403X256576231017110252

Abstract

Background: Congestive Heart Failure with reduced Ejection Fraction (CHFrEF) guidelines adherence is not accessible everywhere, especially in countries with a high prevalence of low socioeconomic status, which resembles many of the middle eastern countries. However, adherence to the guidelines is correlated with lower mortality and morbidity rates.

Objective: We are going to investigate the degree of treatment guideline adherence in CHFrEF in a patient population in the Middle East and correlate the compliance level with morbidity and mortality. Methods and Statistics: A retrospective study conducted on patients with CHFrEF in the Middle East region, maintained on Sacubitril/Valsartan for up to 4 years (190 patients), including a follow-up for morbidity and mortality rates, in addition to their correlations to the level of guidelines adherence.

Results: Statistical analysis was done through IBM SPSS® 27th version. NYHA (pretreatment and post-treatment) was statistically significant in the partial adherence group as well as in full adherence. Moreover, Ejection fraction (pretreatment and post-treatment) was statistically significant in the partial adherence group as well as in full adherence, hence regardless of the level of adherence to the use of Sacubitril/Valsartan in CHFrEF, there was an improvement in the morbidity and mortality rates over up to four years of follow up.

Conclusion: Despite of our full support to full CHFrEF guideline adherence, we recognize how hard this task to be achieved, nevertheless this study supports the theme that any guideline adherence is correlated with better morbidity and mortality rates over a long term follow up.

Keywords: Adherence; Congestive; Guidelines; Heart Failure; Middle East..