Reactive Oxygen Species Modulator 1 Plays an Obligate Role in Cardiomyocyte Hypertrophy

Matthew D Martens; Claudia D Holody; Lisa Wells; Heidi L Silver; Daniela Y Morales-Llamas; William W Du; Courtney Reeks; Mostafa Khairy; Huachen Chen; Mourad Ferdaoussi; Stephane L Bourque; Burton B Yang; John R Ussher; Hélène Lemieux; Gavin Y Oudit; Robert A Screaton; Jason R B Dyck

doi:10.1161/CIRCRESAHA.123.323456

Reactive Oxygen Species Modulator 1 Plays an Obligate Role in Cardiomyocyte Hypertrophy

Circ Res. 2024 Jan 5;134(1):114-116. doi: 10.1161/CIRCRESAHA.123.323456. Epub 2023 Nov 29.

Authors

Matthew D Martens^{1

2

3

4}, Claudia D Holody^{3

4

5

6}, Lisa Wells^{7

8}, Heidi L Silver^{1

2

3

4}, Daniela Y Morales-Llamas^{1

2

3

4}, William W Du^{7

9}, Courtney Reeks^{7

8}, Mostafa Khairy^{1

2

3

4}, Huachen Chen¹, Mourad Ferdaoussi^{1

2

3

10}, Stephane L Bourque^{3

4

5

6}, Burton B Yang^{7

9}, John R Ussher^{1

2

3

11}, Hélène Lemieux^{3

5

10}, Gavin Y Oudit^{1

5}, Robert A Screaton^{7

8}, Jason R B Dyck^{1

2

3

4}

Affiliations

¹ Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
² Alberta Diabetes Institute (M.D.M., H.L.S., D.Y.M.-L., M.K.,.M.F., J.R.U., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
³ Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
⁴ Department of Pediatrics (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., S.L.B., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
⁵ Department of Medicine (C.D.H., H.C., H.L., G.Y.O.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
⁶ Department of Anesthesiology (C.D.H., S.L.B.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
⁷ Sunnybrook Research Institute (L.W., W.W.D., C.R., B.B.Y., R.A.S.), University of Toronto, Ontario, Canada.
⁸ Department of Biochemistry (L.W., C.R., R.A.S.), University of Toronto, Ontario, Canada.
⁹ Department of Laboratory Medicine and Pathobiology (W.W.D., B.B.Y.), University of Toronto, Ontario, Canada.
¹⁰ Faculty Saint-Jean (M.F., H.L.), University of Alberta, Edmonton, Canada.
¹¹ Faculty of Pharmacy and Pharmaceutical Sciences (J.R.U.), University of Alberta, Edmonton, Canada.

PMID: 38018429
DOI: 10.1161/CIRCRESAHA.123.323456

No abstract available

Keywords: electron transport; mitochondrial proteins; reactive oxygen species; respiration; workload.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Hypertrophy / metabolism
Mitochondria*
Myocytes, Cardiac* / metabolism
Reactive Oxygen Species / metabolism

Substances

Reactive Oxygen Species