Clinical efficacy of budesonide combined with acetylcysteine in the treatment of mycoplasma pneumonia infection

Immun Inflamm Dis. 2023 Nov;11(11):e1068. doi: 10.1002/iid3.1068.


Objective: Mycoplasma pneumoniae pneumonia (MPP) is a common respiratory tract infectious disease in children. The study aimed to elucidate the therapeutic efficacy of aerosolized budesonide and N-acetylcysteine combination therapy for MP infection in children.

Methods: One hundred and twenty children with MP infection were included and divided into the control group (received aerosol inhalation of budesonide) and the experimental group (aerosolized budesonide and N-acetylcysteine). After treatment, the disappearance time of clinical symptoms and efficacy were contrasted between the two groups.

Results: With the passage of treatment time, the children's cough score of the two groups were gradually reduced. The children in the experimental group got well from the cough faster than the control group, and the difference reached a significant level on the 5th and 7th days. The time required for fever, rale, and cough to disappear in the experimental group was shorter than those in the control group. As the treatment progressed, a gradual decrease in serum interleukin-6, tumor necrosis factor-α, and C-reactive protein values was detected in both groups, and the decrease was more significant in the experimental group. The total effective rate of the experimental group was 98.33%, which surpassed the control group (93.33%).

Conclusion: Budesonide and N-acetylcysteine combination therapy in the treatment of MP infection in children has a significant effect, and can quickly relieve the clinical symptoms of children with good safety. It is worthy of widespread clinical use.

Keywords: budesonide/N-acetylcysteine combination; inflammatory cytokines; mycoplasma pneumoniae pneumonia; therapy efficacy.

MeSH terms

  • Acetylcysteine / therapeutic use
  • Budesonide / therapeutic use
  • Child
  • Cough
  • Humans
  • Mycoplasma pneumoniae
  • Pneumonia, Mycoplasma* / diagnosis
  • Pneumonia, Mycoplasma* / drug therapy
  • Pneumonia, Mycoplasma* / pathology
  • Treatment Outcome


  • Budesonide
  • Acetylcysteine