Magnesium-free medium activates seizure-like events in the rat hippocampal slice

Brain Res. 1986 Nov 19;398(1):215-9. doi: 10.1016/0006-8993(86)91274-6.


The effect of magnesium-free medium on the electrical activity in CA3 of the rat hippocampal slice was examined. Magnesium removal resulted in the development of spontaneous and triggered interictal-like bursting, followed by spontaneous ictal-like events and finally periodic clustered bursts. The ictal-like events consisted of a tonic firing phase and a phase of clustered burst discharges resembling the tonic and clonic phases of seizures. The return to normal medium resulted in spontaneous and triggered interictal-like bursts.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials
  • Age Factors
  • Animals
  • Electric Stimulation
  • Hippocampus / physiopathology*
  • In Vitro Techniques
  • Magnesium / pharmacology*
  • Magnesium / physiology
  • Male
  • Rats
  • Rats, Inbred Strains
  • Seizures / physiopathology*


  • Magnesium