Dermatological evaluation in dogs with atopic dermatitis treated with full-spectrum high cannabidiol oil: a pre study part 1

Front Vet Sci. 2023 Oct 31:10:1285384. doi: 10.3389/fvets.2023.1285384. eCollection 2023.


Introduction: Dermatological consultations represent a great part of the small animal medical clinic routine. Canine atopic dermatitis (CAD) is a common skin disease that affects a significant amount of dogs, making it a relevant consideration in clinical practice. The role of the endocannabinoid system on skin homeostasis has been described and its deregulation contributes to dermatopathies. Its function in specialized skin cells reveals an expressive therapeutic potential. Due to the difficulties and the growing scientific evidence of the therapeutic benefits of cannabis on animals, this work aimed to evaluate the anti-inflammatory effects of cannabis-derived oil in the treatment of CAD.

Methods: Fourteen canines diagnosed with CAD were divided into two groups: T: full spectrum high cannabidiol (CBD) cannabis oil, 2,5 mg/kg; and C: control group (treated with olive oil alone). The effectiveness was evaluated based on the degree of pruritus, dermatological evaluation (CADESI-4) and histopathological evaluation of the skin including mast cell count.

Results: Despite the theoretical basis, there were no significant results obtained between the compared treatments.

Discussion: Thus, it can be concluded that although full spectrum high cannabinoids therapy presents a promising approach to immunological diseases, further research is required in order to establish the actual effective cannabinoid ratio within the myriad possible combinations and for multi-target therapy of CAD.

Keywords: canine atopic dermatitis; cannabidiol; cannabis; histopathology; mast cell count; veterinary dermatology.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The Brazilian Association of Medicinal Cannabis Patients (AMA+ME) supported with CBD oil and is partially funding the publication fees. The Coordination for the Improvement of Higher Education Personnel (CAPES) funded the CM with a postgraduate scholarship (88887.821860/2023-00).