Cartilage organoids and osteoarthritis research: a narrative review

Daofu Zeng; Yeping Chen; Zhidong Liao; Guizheng Wei; Xiajie Huang; Rongyuan Liang; William W Lu; Dan Yi; Yan Chen

doi:10.3389/fbioe.2023.1278692

Cartilage organoids and osteoarthritis research: a narrative review

Front Bioeng Biotechnol. 2023 Nov 9:11:1278692. doi: 10.3389/fbioe.2023.1278692. eCollection 2023.

Authors

Daofu Zeng^#^{1

2}, Yeping Chen^#², Zhidong Liao¹, Guizheng Wei², Xiajie Huang¹, Rongyuan Liang², William W Lu³, Dan Yi^{4

5}, Yan Chen^{1

2}

Affiliations

¹ Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed by the Province and Ministry, Guangxi Medical University, Nanning, Guangxi, China.
² Department of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
³ Department of Orthopedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
⁴ Research Center for Computer-Aided Drug Discovery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
⁵ Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

^# Contributed equally.

Abstract

Osteoarthritis (OA) is one of the most common degenerative joint diseases, significantly impacting individuals and society. With the acceleration of global aging, the incidence of OA is increasing. The pathogenesis of osteoarthritis is not fully understood, and there is no effective way to alleviate the progression of osteoarthritis. Therefore, it is necessary to develop new disease models and seek new treatments for OA. Cartilage organoids are three-dimensional tissue masses that can simulate organ structure and physiological function and play an important role in disease modeling, drug screening, and regenerative medicine. This review will briefly analyze the research progress of OA, focusing on the construction and current development of cartilage organoids, and then describe the application of cartilage organoids in OA modeling, drug screening, and regeneration and repair of cartilage and bone defects. Finally, some challenges and prospects in the development of cartilaginous organoids are discussed.

Keywords: cartilage organoids; disease model; organoids; osteoarthritis; regeneration and repair.

Publication types

Review

Grants and funding

The authors declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by grants from National Natural Science Foundation of China (82060406), Natural Science Foundation of Guangxi (2022JJA141126), Advanced Innovation Teams and Xinghu Scholars Program of Guangxi Medical University, China Postdoctoral Science Foundation (2019M650235), Key R&D Project of Qingxiu District, Nanning, Guangxi (2021003), and Guangdong Basic and Applied Basic Research Foundation grant (2021A1515111075).