Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 7 (3), 177-88

Meta-analysis in Clinical Trials

Meta-analysis in Clinical Trials

R DerSimonian et al. Control Clin Trials.

Abstract

This paper examines eight published reviews each reporting results from several related trials. Each review pools the results from the relevant trials in order to evaluate the efficacy of a certain treatment for a specified medical condition. These reviews lack consistent assessment of homogeneity of treatment effect before pooling. We discuss a random effects approach to combining evidence from a series of experiments comparing two treatments. This approach incorporates the heterogeneity of effects in the analysis of the overall treatment efficacy. The model can be extended to include relevant covariates which would reduce the heterogeneity and allow for more specific therapeutic recommendations. We suggest a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.

Comment in

Similar articles

  • Meta-analysis in Clinical Trials Revisited
    R DerSimonian et al. Contemp Clin Trials 45 (Pt A), 139-45. PMID 26343745.
    In this paper, we revisit a 1986 article we published in this Journal, Meta-Analysis in Clinical Trials, where we introduced a random-effects model to summarize the evide …
  • Patient Heterogeneity in Clinical Trials
    R Simon. Cancer Treat Rep 64 (2-3), 405-10. PMID 7407777.
    Interpretation of therapeutic results is complicated by variability in response among patients. This paper reviews fundamental statistical principles for the design of cl …
  • Healthcare Outcomes Assessed With Observational Study Designs Compared With Those Assessed in Randomized Trials
    A Anglemyer et al. Cochrane Database Syst Rev (4), MR000034. PMID 24782322. - Review
    Our results across all reviews (pooled ROR 1.08) are very similar to results reported by similarly conducted reviews. As such, we have reached similar conclusions; on ave …
  • Palliative Treatment of Cancer-Related Pain [Internet]
    U Kongsgaard et al. PMID 29320015. - Review
    RCTs of cancer pain control often enroll few subjects, have low methodological quality and involve heterogeneous interventions and outcome measures assessed by different …
  • A Quality-Effects Model for Meta-Analysis
    SA Doi et al. Epidemiology 19 (1), 94-100. PMID 18090860.
    We introduce a quality-effects approach that combines evidence from a series of trials comparing 2 interventions. This approach incorporates the heterogeneity of effects …
See all similar articles

Cited by 9,122 PubMed Central articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback