BNIP3 as a new tool to promote healthy brain aging

Kit Neikirk; Andrea G Marshall; Monica M Santisteban; Antentor Hinton Jr

doi:10.1111/acel.14042

BNIP3 as a new tool to promote healthy brain aging

Aging Cell. 2024 Feb;23(2):e14042. doi: 10.1111/acel.14042. Epub 2023 Nov 29.

Authors

Kit Neikirk¹, Andrea G Marshall¹, Monica M Santisteban², Antentor Hinton Jr¹

Affiliations

¹ Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
² Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Abstract

The article "Neuronal induction of BNIP3-mediated mitophagy slows systemic aging in Drosophila" reveals BCL2-interacting protein 3 as a therapeutic target to counteract brain aging and prolong overall organismal health with age. In this spotlight, we consider the roles of BNIP3, a mitochondrial outer membrane protein, in the adult nervous system, including its induction of mitophagy and prevention of dysfunctional mitochondria in the aged brain. Implications for other tissue types to reduce the burden of aging are further considered.

Keywords: BNIP3; age-related pathology; aging; mitochondria; neuronal.

Publication types

Review

MeSH terms

Brain / metabolism
Mitochondria* / metabolism
Mitochondrial Proteins* / metabolism
Mitophagy

Substances

Mitochondrial Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding