Campylobacter jejuni uses energy taxis and a dehydrogenase enzyme for l-fucose chemotaxis

mBio. 2023 Dec 19;14(6):e0273223. doi: 10.1128/mbio.02732-23. Epub 2023 Nov 30.

Abstract

In this study, we identify a separate role for the Campylobacter jejuni l-fucose dehydrogenase in l-fucose chemotaxis and demonstrate that this mechanism is not only limited to C. jejuni but is also present in Burkholderia multivorans. We now hypothesize that l-fucose energy taxis may contribute to the reduction of l-fucose-metabolizing strains of C. jejuni from the gastrointestinal tract of breastfed infants, selecting for isolates with increased colonization potential.

Keywords: Campylobacter jejuni; chemotaxis; energy taxis; l-fucose.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Burkholderia / enzymology
  • Burkholderia / genetics
  • Campylobacter jejuni* / enzymology
  • Campylobacter jejuni* / genetics
  • Chemotaxis*
  • Energy Metabolism
  • Fucose* / metabolism
  • Gastrointestinal Tract / microbiology
  • Humans

Substances

  • Fucose