Fecal microbiota transplantation: a novel strategy for treating Alzheimer's disease

Wu Xiang; Han Xiang; Junyu Wang; Yiqin Jiang; Chuanhui Pan; Bingjin Ji; Anren Zhang

doi:10.3389/fmicb.2023.1281233

Fecal microbiota transplantation: a novel strategy for treating Alzheimer's disease

Front Microbiol. 2023 Nov 16:14:1281233. doi: 10.3389/fmicb.2023.1281233. eCollection 2023.

Authors

Wu Xiang^#^{1

2}, Han Xiang^#³, Junyu Wang^#², Yiqin Jiang¹, Chuanhui Pan¹, Bingjin Ji¹, Anren Zhang²

Affiliations

¹ Department of Rehabilitation, Beibei Traditional Chinese Medical Hospital, Chongqing, China.
² Department of Rehabilitation Medicine, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
³ Department of Radiology, Daping Hospital, Army Medical University, Chongqing, China.

^# Contributed equally.

Abstract

Alzheimer's disease is a common neurological disorder, which has become one of the major factors affecting human health due to its serious impact on individuals, families and society. It has been confirmed that gut microbiota can affect the occurrence and development of Alzheimer's disease. Especially, fecal microbiota transplantation plays a positive role in the treatment of Alzheimer's disease. The mechanisms for improving Alzheimer's disease might include anti-inflammation and regulation of amyloid β-protein, synaptic plasticity, short-chain fatty acids, and histone acetylation. In this mini-review, the relationship between fecal microbiota transplantation and Alzheimer's disease was summarized. It is hoped that fecal microbiota transplantation would play a positive role in the prevention and treatment of Alzheimer's disease in the future.

Keywords: Alzheimer’s disease; fecal microbiota transplantation; gut microbiota; mechanism; review.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the General Program of National Natural Science Foundation of China (81973927), the Key R&D Program of Sichuan Department of Science and Technology (2021YFS0133), the Special Project for Scientific Research of Traditional Chinese Medicine in Sichuan Province (2020), the Special Project of Traditional Chinese Medicine Scientific Research of Sichuan Provincial Administration of Traditional Chinese Medicine (2020LC0224), the Hospital Project of the General Hospital of the Western Theater (2019), and the Chongqing Beibei District Science and Technology Bureau Project (2022-18).