Small cell neuroendocrine carcinoma with adenocarcinoma and high grade squamous intraepithelial neoplasia of the cervix

Guralarasan Gurubalan; Amber Parwaiz; Surabhi Ajit; Tarun Kumar; Madhu Kumari; Punam Bhadani

doi:10.4322/acr.2023.452

Small cell neuroendocrine carcinoma with adenocarcinoma and high grade squamous intraepithelial neoplasia of the cervix

Autops Case Rep. 2023 Nov 13:13:e2023452. doi: 10.4322/acr.2023.452. eCollection 2023.

Authors

Guralarasan Gurubalan¹, Amber Parwaiz¹, Surabhi Ajit¹, Tarun Kumar¹, Madhu Kumari¹, Punam Bhadani¹

Affiliation

¹ All India Institute of Medical Sciences, Patna, Bihar, India.

Abstract

Neuroendocrine neoplasm (NEN) of the cervix is a malignant tumor and is classified into low and intermediate-grade neuroendocrine tumor (NET), and high-grade small cell neuroendocrine carcinoma (SCNEC), and large cells neuroendocrine carcinoma (LCNEC). SCNEC of the cervix is an Infrequent tumor with an incidence of less than 1% of all gynecological malignancies. It is characterized by small to medium-sized tumor cells with scant cytoplasm and neuroendocrine differentiation. Most cases of SCNEC of the cervix manifest in pure forms, and only cases show coexisting, non-neuroendocrine component of HPV-associated adenocarcinoma or squamous cell carcinoma. In this report, reviewing the literature, we present one such unique case of SCNEC of the cervix with adenocarcinoma and high-grade squamous intraepithelial neoplasia.

Keywords: Adenocarcinoma; Human Papillomavirus Viruses; Neuroendocrine Tumors; Squamous Intraepithelial Lesions.

Publication types

Case Reports