Development and evaluation of anti-reflux functional-oral suspension raft composed of sodium alginate-mung bean protein complex

Farzaneh Kamandloo; Maryam Salami; Fatemeh Ghamari; Seyed-Behnam Ghaffari; Zahra EmamDjomeh; Atiyeh Ghasemi; John F Kennedy

doi:10.1016/j.ijbiomac.2023.128490

Development and evaluation of anti-reflux functional-oral suspension raft composed of sodium alginate-mung bean protein complex

Int J Biol Macromol. 2024 Jan;256(Pt 2):128490. doi: 10.1016/j.ijbiomac.2023.128490. Epub 2023 Nov 28.

Authors

Farzaneh Kamandloo¹, Maryam Salami², Fatemeh Ghamari³, Seyed-Behnam Ghaffari⁴, Zahra EmamDjomeh⁵, Atiyeh Ghasemi⁶, John F Kennedy⁷

Affiliations

¹ Transfer Phenomena Laboratory (TPL), Department of Food Science and Engineering, College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran.
² Transfer Phenomena Laboratory (TPL), Department of Food Science and Engineering, College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran; Functional Food Research Core (FRC), University of Tehran, Iran. Electronic address: msalami@ut.ac.ir.
³ Department of Science Payame Noor University, P.O. box 19395-4697, Tehran, Iran.
⁴ School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
⁵ Transfer Phenomena Laboratory (TPL), Department of Food Science and Engineering, College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran; Functional Food Research Core (FRC), University of Tehran, Iran.
⁶ Institute of Biochemistry and Biophysics, University of Tehran, Iran.
⁷ Chembiotech Laboratories Ltd, Tenbury Wells, United Kingdom.

PMID: 38035967
DOI: 10.1016/j.ijbiomac.2023.128490

Abstract

This study aimed to develop a sodium alginate (Na alginate) and mung bean protein (MBP) raft complex to improve gastric reflux symptoms. Na alginate and MBP complexes with different ratios (1:1, 2:1, and 3:1, respectively) were used for raft formulations through a wet Maillard reaction. Structural properties of raft strength, reflux resistance, intrinsic fluorescence emission spectroscopy, and Fourier transform infrared spectroscopy (FTIR) were investigated for rafts. The suspension 1:1 Na alginate/MBP with 0 h Maillard reaction time exhibited the lowest sedimentation volume among the suspensions. In contrast, 3:1 Na alginate/MBP with 6 h Maillard reaction time showed the highest sedimentation volume. Based on the results, the 3:1 Na alginate/MBP rafts had the best results, and the results were within acceptable limits. Functional properties, including antioxidant properties, the Helicobacter pylori inhibition assay, the pancreatic lipase inhibition assay, and angiotensin-converting enzyme (ACE) inhibition, were investigated for rafts. The Na alginate/MBP raft has similar characteristics to Gaviscon syrup and can be used for obesity, Helicobacter pylori infection, high blood pressure, and gastric reflux.

Keywords: Drug-polymer complex; Gastric reflux; Mung bean protein; Raft; Sodium alginate.

MeSH terms

Alginates / chemistry
Antacids / chemistry
Gastroesophageal Reflux* / drug therapy
Helicobacter Infections* / drug therapy
Helicobacter pylori* / metabolism
Humans
Vigna* / metabolism

Substances

Antacids
Alginates