Partial cellular reprogramming: A deep dive into an emerging rejuvenation technology

Aging Cell. 2024 Feb;23(2):e14039. doi: 10.1111/acel.14039. Epub 2023 Dec 1.


Aging and age-associated disease are a major medical and societal burden in need of effective treatments. Cellular reprogramming is a biological process capable of modulating cell fate and cellular age. Harnessing the rejuvenating benefits without altering cell identity via partial cellular reprogramming has emerged as a novel translational strategy with therapeutic potential and strong commercial interests. Here, we explore the aging-related benefits of partial cellular reprogramming while examining limitations and future directions for the field.

Keywords: aging; aging hallmarks; lifespan; partial cellular reprogramming; rejuvenation.

Publication types

  • Review

MeSH terms

  • Cell Differentiation
  • Cellular Reprogramming* / genetics
  • Cellular Senescence
  • Rejuvenation*