Red cell exchange for rapid leukoreduction in adults with hyperleukocytosis and leukostasis

Blood. 2023 Dec 5:blood.2023021895. doi: 10.1182/blood.2023021895. Online ahead of print.


We show for the first time that red cell exchange (RCE) treats hyperleukocytosis in acute leukemia. RCE provided similar leukoreduction to standard therapeutic leukoreduction and could be superior in patients with severe anemia, monocytic leukemias, or when requiring rapid treatment.