Testicular involvement in mantle cell lymphoma: An analysis of 16 patients

Samer Alkhalili; Dharmini Manogna; Hana Safah; Elizabeth Ellent; Walter Beversdorf; Ruby Arora; Nakhle S Saba

doi:10.1016/j.lrr.2023.100397

Testicular involvement in mantle cell lymphoma: An analysis of 16 patients

Leuk Res Rep. 2023 Nov 15:20:100397. doi: 10.1016/j.lrr.2023.100397. eCollection 2023.

Authors

Samer Alkhalili¹, Dharmini Manogna², Hana Safah², Elizabeth Ellent³, Walter Beversdorf⁴, Ruby Arora⁵, Nakhle S Saba²

Affiliations

¹ Deming Department of Medicine, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112, United States.
² Section of Hematology and Medical Oncology, Deming Department of Medicine, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112, United States.
³ Hematology and Medical Oncology, LCMC Health, 4513 Westbank Expressway, Marrero, LA 70072, United States.
⁴ Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112, United States.
⁵ Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112, United States.

Abstract

Mantle cell lymphoma (MCL) with testicular involvement is a rare presentation and only a few cases have been described in the literature. We present a case of MCL with testicular involvement and the first analysis of all previously reported cases assessing trends in immunohistochemical features, prognostic indicators, and survival. Our data suggest that among all MCL, testicular MCL is more likely to present with aggressive features: blastoid/pleomorphic morphology, high Ki-67 proliferative index, and CNS involvement. Testicular MCL is also associated with shorter overall survival.

Keywords: Cyclin-D1; MCL; NHL; PTL; Testicular lymphoma.

Publication types

Case Reports