A New Zn(II) Compound: Luminescent Property and Promoting Knee Cartilage Repair by Modulating Iron Death

Hai Wang; Hongjiu Qiu; Chuanjiang Xie; Jifeng Zhu

doi:10.1007/s10895-023-03530-7

A New Zn(II) Compound: Luminescent Property and Promoting Knee Cartilage Repair by Modulating Iron Death

J Fluoresc. 2023 Dec 6. doi: 10.1007/s10895-023-03530-7. Online ahead of print.

Authors

Hai Wang¹, Hongjiu Qiu¹, Chuanjiang Xie¹, Jifeng Zhu²

Affiliations

¹ Department of Orthopaedics, Daping Hospital, Army Medical University, Chongqing, 400042, China.
² Department of Orthopaedics, Daping Hospital, Army Medical University, Chongqing, 400042, China. JifengZhu10@163.com.

PMID: 38055141
DOI: 10.1007/s10895-023-03530-7

Abstract

The hydrothermal reactions of bis{6-{5-methyl-1 H,7 H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one}}methane (L) and Zn(NO₃)₂·6H₂O at 180 ℃ afforded a novel Zn(II) coordination polymer (CP), that is, {[Zn₂(L)(µ₂-O)₂]·3H₂O}_n (1), which further characterized via Single crystal X-ray diffraction (SCXRD), elemental analysis (EA), powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA). Besides, this CP reveals strong luminescence that may be caused by the charge transfer within the ligand. In biological study, the new compound was evaluated for its protective effect on chondrocytes. This compound significantly up-regulated GPX4 and down-regulated HO-1 mRNA levels, thereby inhibiting iron death in chondrocytes.

Keywords: Knee cartilage repair; Luminescence; Zn(II) compound.