[DL-phenylalanine as an antidepressant. Open study (author's transl)]

Arzneimittelforschung. 1978;28(8):1283-4.
[Article in German]


In an open study dl-phenylalanine in doses from 75--200 mg/day was administered to 20 depressed patients for 20 days. At the end of the trial 12 patients (8 with complete, 4 with good response) could be discharged without any further treatment. 4 patients with partially untypical depressions experienced mild to moderate responses, whereas 4 patients did not respond at all to the phenylalanine administration. Depressive "core symptoms" as depressed mood, retardation and/or agitation were preferentially, anxiety and sleep disturbances moderately and hypochondriasis and compulsiveness were not influenced. It is concluded that dl-phenylalanine might have substantial antidepressant properties and that further controlled investigations are justified.

Publication types

  • Clinical Trial
  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Clinical Trials as Topic
  • Depression / drug therapy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Phenylalanine / therapeutic use*
  • Placebos
  • Time Factors


  • Placebos
  • Phenylalanine