Progressive Ataxia and Palatal Tremor Is Not Associated with IgLON5 Antibodies: Results From Two Cases

Andrea Mastrangelo; Maria Pia Giannoccaro; Vincenzo Donadio; Fortuna Ricciardiello; Felice Di Laudo; Flavia Palombo; Rocco Liguori; Giovanni Rizzo

doi:10.1007/s12311-023-01647-w

Progressive Ataxia and Palatal Tremor Is Not Associated with IgLON5 Antibodies: Results From Two Cases

Cerebellum. 2023 Dec 7. doi: 10.1007/s12311-023-01647-w. Online ahead of print.

Authors

Andrea Mastrangelo¹, Maria Pia Giannoccaro^{1

2}, Vincenzo Donadio², Fortuna Ricciardiello², Felice Di Laudo¹, Flavia Palombo³, Rocco Liguori^{1

2}, Giovanni Rizzo⁴

Affiliations

¹ Department of Biomedical and Neuromotor Sciences, University of Bologna (DIBINEM), Bologna, Italy.
² IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.
³ IRCCS Istituto delle Scienze Neurologiche di Bologna, Programma di Neurogenetica, Ospedale Bellaria, Via Altura 1/8, 40139, Bologna, Italy.
⁴ IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy. g.rizzo@unibo.it.

PMID: 38060151
DOI: 10.1007/s12311-023-01647-w

Abstract

Progressive ataxia and palatal tremor (PAPT) and anti-IgLON5 disease share possible clinical presentations. Furthermore, both have been associated to a tauopathy mainly affecting the brainstem. Nonetheless, anti-IgLON5 antibodies have never been tested in PAPT. We report on two PAPT cases without evidence of anti-IgLON5 antibodies in both CSF and serum. Despite common clinical and pathological characteristics, PAPT and IgLON5 disease are two distinct entities.

Keywords: Ataxia; IgLON5; Neuroimmunology; PAPT; Palatal tremor.