Wound healing efficacy of a polymeric spray film solution containing Centella asiatica leaf extract on acute wounds

J Wound Care. 2023 Dec 1;32(Sup12):S22-S32. doi: 10.12968/jowc.2023.32.Sup12.S22.


Objective: To study the clinical efficacy of a polymeric spray film containing Centella asiatica extract to heal acute wounds.

Method: A polymeric spray film solution for wound healing was formulated using Centella asiatica extract, which contained triterpenes, including asiatic acid, madecassic acid, asiaticoside and madecassoside. The stability and physicochemical properties of the formulation were evaluated, and a multicentre, randomised, controlled trial was conducted to assess its clinical wound-healing efficacy. The Pressure Ulcer Scale for Healing (PUSH Tool) score was used to evaluate wound healing on days 0, 3, 5 and 7.

Results: The cohort consisted of 60 volunteers with clean-contaminated wounds (class 1), randomly assigned to the Control (n=30) and Testing (n=30) groups. The spray product contained asiatic acid, madecassic acid, asiaticoside and madecassoside at 0.20±0.02mg/ml, 0.16±0.01mg/ml, 0.32±0.03mg/ml and 0.10±0.00mg/ml, respectively. The pH value was 5.5±0.01, and the viscosity was 33±4cP. The product was stable for six months when stored at 30±2°C and at 40±2°C, in 75±5% relative humidity. The tested product significantly reduced the total PUSH and exudate scores, indicating that the polymeric spray film solution containing Centella asiatica improved wound healing. The average healing recovery times for the Testing and Control groups were 4.6±1.1 days and 4.87±1.0 days, respectively.

Conclusion: In this study, Centella asiatica extract-containing polymeric spray film solution was beneficial as an acute wound medication, which could shorten healing time with no adverse effects.

Keywords: Centella asiatica leaf extract; PUSH tool; clinical efficacy testing; polymeric spray film solution; wound; wound care; wound dressing; wound healing.

Publication types

  • Randomized Controlled Trial
  • Multicenter Study

MeSH terms

  • Centella* / chemistry
  • Humans
  • Plant Extracts / pharmacology
  • Polymers / pharmacology
  • Wound Healing


  • madecassoside
  • madecassic acid
  • asiaticoside
  • asiatic acid
  • Plant Extracts
  • Polymers