Toward a CRISPR understanding of gene function in human brain development

Emmy Li; Martin Kampmann

doi:10.1016/j.stem.2023.11.005

Toward a CRISPR understanding of gene function in human brain development

Cell Stem Cell. 2023 Dec 7;30(12):1561-1562. doi: 10.1016/j.stem.2023.11.005.

Authors

Emmy Li¹, Martin Kampmann²

Affiliations

¹ Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA. Electronic address: emmy.li@ucsf.edu.
² Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. Electronic address: martin.kampmann@ucsf.edu.

PMID: 38065064
DOI: 10.1016/j.stem.2023.11.005

Abstract

Genome-wide association studies pinpoint genetic risk factors for neurodevelopmental disorders (NDDs), but the next challenge is to understand the mechanisms through which these genes affect brain development. Two recent CRISPR screens in human brain organoids¹^,² interrogate the function of risk genes for autism spectrum disorder and other NDDs.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Autism Spectrum Disorder* / genetics
Brain
Clustered Regularly Interspaced Short Palindromic Repeats / genetics
Genome-Wide Association Study
Humans
Neurodevelopmental Disorders*

Abstract

Publication types

MeSH terms

Grants and funding