Ca2+ binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing

Han Chen; Mehar Monga; Qinghua Fang; Loujin Slitin; Jakob Neef; Shashank S Chepurwar; Regina Célia Mingroni Netto; Karina Lezirovitz; Alfredo Tabith Jr; Fritz Benseler; Nils Brose; Kathrin Kusch; Carolin Wichmann; Nicola Strenzke; Barbara Vona; Julia Preobraschenski; Tobias Moser

doi:10.1093/procel/pwad058

Ca2+ binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing

Protein Cell. 2024 Apr 1;15(4):305-312. doi: 10.1093/procel/pwad058.

Authors

Han Chen^{1

2

3

4}, Mehar Monga^{2

4

5}, Qinghua Fang^{1

2

3}, Loujin Slitin^{1

4

6

7}, Jakob Neef^{1

2

3}, Shashank S Chepurwar^{2

4

8}, Regina Célia Mingroni Netto⁹, Karina Lezirovitz¹⁰, Alfredo Tabith Jr¹¹, Fritz Benseler¹², Nils Brose^{2

12

13}, Kathrin Kusch^{1

14}, Carolin Wichmann^{2

6

7

13}, Nicola Strenzke^{1

2

8}, Barbara Vona^{1

15

16}, Julia Preobraschenski^{2

5

13}, Tobias Moser^{1

2

3

13}

Affiliations

¹ Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.
² Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.
³ Auditory Neuroscience and Synaptic Nanophysiology Group, Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany.
⁴ Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences, University of Göttingen, 37075 Göttingen, Germany.
⁵ Biochemistry of Membrane Dynamics Group, Institute for Auditory Neuroscience, University Medical Center Göttingen, 37075 Göttingen, Germany.
⁶ Molecular Architecture of Synapses Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.
⁷ Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37075 Göttingen, Germany.
⁸ Auditory Systems Physiology Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.
⁹ Departamento de Genética e Biologia Evolutiva, Centro de Pesquisas sobre o Genoma Humano e Células-Tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo 05508-220, Brazil.
¹⁰ Laboratório de Otorrinolaringologia/LIM32, Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP 05508-220, Brazil.
¹¹ DERDIC, Pontifícia Universidade Católica de São Paulo, São Paulo 05508-220, Brazil.
¹² Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany.
¹³ Multiscale Bioimaging Cluster of Excellence (MBExC), University of Göttingen, 37075 Göttingen, Germany.
¹⁴ Functional Auditory Genomics Group, Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, 37077 Göttingen, Germany.
¹⁵ Hearing Genomics Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.
¹⁶ Institute of Human Genetics, University Medical Center Göttingen, 37075 Göttingen, Germany.

No abstract available

MeSH terms

Calcium* / metabolism
Exocytosis
Hair
Hair Cells, Auditory* / metabolism
Hearing
Synapses / metabolism

Substances

Calcium