Polydopamine nanomaterials and their potential applications in the treatment of autoimmune diseases

Manxiang Wu; Chengyuan Hong; Chunjuan Shen; Dong Xie; Tianxiang Chen; Aiguo Wu; Qiang Li

doi:10.1080/10717544.2023.2289846

Polydopamine nanomaterials and their potential applications in the treatment of autoimmune diseases

Drug Deliv. 2023 Dec;30(1):2289846. doi: 10.1080/10717544.2023.2289846. Epub 2023 Dec 9.

Authors

Manxiang Wu^{1

2}, Chengyuan Hong^{1

3}, Chunjuan Shen⁴, Dong Xie^{1

2}, Tianxiang Chen¹, Aiguo Wu¹, Qiang Li²

Affiliations

¹ Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo, China.
² Department of Radiology, The Affiliated People's Hospital of Ningbo University, Ningbo, P. R. China.
³ Department of Mechanical, Materials and Manufacturing Engineering, University of Nottingham Ningbo China, Ningbo, P. R. China.
⁴ Center for Reproductive Medicine, Jiaxing University Affilated Maternity and Child Hospital, Jiaxing, P. R. China.

Abstract

The conventional treatment methods used for the management of autoimmune diseases (ADs) have limited efficacy and also exhibit significant side effects. Thus, identification of novel strategies to improve the efficacy and safety of ADs treatment is urgently required. Overactivated immune response and oxidative stress are common characteristics associated with ADs. Polydopamine (PDA), as a polymer material with good antioxidant and photothermal conversion properties, has displayed useful application potential against ADs. In addition, PDA possesses good biosafety, simple preparation, and easy functionalization, which is conducive for the pharmacological development of PDA nanomaterials with clinical transformation prospects. Here, we have first reviewed the preparation of PDA, the different functional integration strategies of PDA-based biomaterials, and their potential applications in ADs. Next, the mechanism of action of PDA in ADs has been elaborated in detail. Finally, the application opportunities and challenges linked with PDA nanomaterials for ADs treatment are discussed. This review is contributed to design reasonable and effective PDA nanomaterials for the diagnosis and treatment of ADs.

Keywords: Polydopamine; antioxidant; autoimmune diseases; immunomodulation; photothermal therapy.

Publication types

Review

MeSH terms

Indoles / pharmacology
Indoles / therapeutic use
Nanostructures*
Phototherapy
Polymers / pharmacology

Substances

polydopamine
Indoles
Polymers

Grants and funding

This work was supported by the funding from Ningbo Natural Science Foundation [2021J019, 2023J386, 2023J021], Zhejiang Medical and Health Science and Technology Plan Project [2022RC251], Ningbo Clinical Research Center for Medical Imaging [Grant No.2021L003: 2022LYKFZD01, 2022LYKEYB02, 2022LYKFYB05], National Natural Science Foundation of China [32025021, 51873225], 2021Z054 Ningbo major science and technology task project [Nos.2021Z054], Ningbo Clinical Research Center for Ophthalmology and the Project of NINGBO Leading Medical&Health Disipline [2016-S05], Ningbo Science and Technology Public Welfare Project [2022S26, 2022S133], the Strategic Priority Research Program of Chinese Academy of Sciences [Grant No. XDB36000000], Key Scientific and Technological Special Project of Ningbo City [2017C110022], Provincial and Municipal Co-construction Key Discipline for Medical Imaging [No. 2022-S02].