DNA-Encoded Chemical Libraries (DELs) have gained momentum over the recent years for the discovery of small-molecule ligands and the technology has been integrated in most of the larger pharmaceutical companies. With this perspective we would like to summarize the development of DEL technology and present some representative DEL-derived hits which may soon enter the pharmaceutical market.
Keywords: DNA-Encoded Chemical Library; affinity-based screening; small-molecule drug discovery.
Copyright 2022 Michelle Keller, Kristina Schira, Jörg Scheuermann. License: This work is licensed under a Creative Commons Attribution 4.0 International License.