[Management of adverse events of CAR-T therapy]

Rinsho Ketsueki. 2023;64(11):1465-1469. doi: 10.11406/rinketsu.64.1465.
[Article in Japanese]

Abstract

Chimeric antigen receptor T cell (CAR-T) therapy has strong efficacy as well as characteristic complications. Although overshadowed by the glaring clinical picture of cytokine releasing syndrome and immune effector cell-associated neurotoxicity syndrome, there are many other side effects that are important to manage. In this article, CAR-T-specific adverse events will be reviewed based on the actual clinical experience.

Keywords: Adverse events; Chimeric antigen receptor T cell; Cytokine releasing syndrome; Management.

Publication types

  • English Abstract

MeSH terms

  • Cell- and Tissue-Based Therapy
  • Humans
  • Immunotherapy, Adoptive / adverse effects
  • Receptors, Antigen, T-Cell
  • Receptors, Chimeric Antigen*

Substances

  • Receptors, Chimeric Antigen
  • Receptors, Antigen, T-Cell