Short term metronidazole therapy contrasted with povidone-iodine spray in the prevention of wound infection after appendicectomy

Br J Surg. 1979 Jun;66(6):430-1. doi: 10.1002/bjs.1800660618.


In a prospective, randomized trial metronidazole was found to be significantly better than povidone-iodine in reducing the incidence of wound infection after appendicectomy (P less than 0.005). The metronidazole was given as a established 7-day course. Over 65 per cent of the wound infections presented after the patients had been discharged from hospital.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aerosols
  • Appendectomy*
  • Child
  • Clinical Trials as Topic
  • Humans
  • Metronidazole / therapeutic use*
  • Povidone / analogs & derivatives*
  • Povidone-Iodine / therapeutic use*
  • Random Allocation
  • Surgical Wound Infection / prevention & control*
  • Time Factors


  • Aerosols
  • Metronidazole
  • Povidone-Iodine
  • Povidone