The role of SARS-COV-2 infection in promoting abnormal immune response and sepsis: A comparison between SARS-COV-2-related sepsis and sepsis from other causes

Infect Med (Beijing). 2023 Apr 28;2(3):202-211. doi: 10.1016/j.imj.2023.04.006. eCollection 2023 Sep.


Background: COVID-19 caused by SARS-CoV-2 virus is characterized by respiratory compromise and immune system involvement, even leading to serious disorders, such as cytokine storm.

Methods: We then conducted a literature review on the topic of sepsis and covid-19, and in parallel conducted an experimental study on the histological finding of patients who died from SARS-Covid 19 infection and a control group.

Results: Sepsis associated with covid-19 infection has some similarities and differences from that from other causes.

Conclusion: In this paper the complex interplay between the 2 disorders was discussed, focusing on the similarities and on the effect that one could have on the other. A preliminary experimental section that demonstrates the multisystemic involvement in subjects who die from SARS-CoV-2 is also proposed.

Keywords: Cytokine storm; SARS-COV-2; SARS-CoV-2; Sepsis; Septic shock.