Abstract
Colloidal carriers injected intravenously are normally removed rapidly and efficiently by the liver and this represents a major barrier to drug targeting. By coating model microspheres and emulsions with a block co-polymer (poloxamine) it has been possible to keep the carrier circulating in the vascular compartment with little or no uptake by the reticuloendothelial system.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Colloids*
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Ethylenediamines*
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Kidney / metabolism
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Liver / metabolism*
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Lung / metabolism
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Microspheres
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Myocardium / metabolism
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Poloxalene / metabolism
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Polyethylene Glycols*
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Polymers / metabolism*
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Polystyrenes / metabolism*
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Rabbits
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Spleen / metabolism*
Substances
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Colloids
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Ethylenediamines
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Polymers
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Polystyrenes
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tetronic 701
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Polyethylene Glycols
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Poloxalene