The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilized with a block copolymer--poloxamine 908

Life Sci. 1987 Jan 26;40(4):367-74. doi: 10.1016/0024-3205(87)90138-x.

Abstract

Colloidal carriers injected intravenously are normally removed rapidly and efficiently by the liver and this represents a major barrier to drug targeting. By coating model microspheres and emulsions with a block co-polymer (poloxamine) it has been possible to keep the carrier circulating in the vascular compartment with little or no uptake by the reticuloendothelial system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Colloids*
  • Ethylenediamines*
  • Kidney / metabolism
  • Liver / metabolism*
  • Lung / metabolism
  • Microspheres
  • Myocardium / metabolism
  • Poloxalene / metabolism
  • Polyethylene Glycols*
  • Polymers / metabolism*
  • Polystyrenes / metabolism*
  • Rabbits
  • Spleen / metabolism*

Substances

  • Colloids
  • Ethylenediamines
  • Polymers
  • Polystyrenes
  • tetronic 701
  • Polyethylene Glycols
  • Poloxalene