Endoscopic En Bloc Versus Piecemeal Resection of Large Nonpedunculated Colonic Adenomas : A Randomized Comparative Trial

Ann Intern Med. 2024 Jan;177(1):29-38. doi: 10.7326/M23-1812. Epub 2023 Dec 12.


Background: Endoscopic resection of adenomas prevents colorectal cancer, but the optimal technique for larger lesions is controversial. Piecemeal endoscopic mucosal resection (EMR) has a low adverse event (AE) rate but a variable recurrence rate necessitating early follow-up. Endoscopic submucosal dissection (ESD) can reduce recurrence but may increase AEs.

Objective: To compare ESD and EMR for large colonic adenomas.

Design: Participant-masked, parallel-group, superiority, randomized controlled trial. (ClinicalTrials.gov: NCT03962868).

Setting: Multicenter study involving 6 French referral centers from November 2019 to February 2021.

Participants: Patients with large (≥25 mm) benign colonic lesions referred for resection.

Intervention: The patients were randomly assigned by computer 1:1 (stratification by lesion location and center) to ESD or EMR.

Measurements: The primary end point was 6-month local recurrence (neoplastic tissue on endoscopic assessment and scar biopsy). The secondary end points were technical failure, en bloc R0 resection, and cumulative AEs.

Results: In total, 360 patients were randomly assigned to ESD (n = 178) or EMR (n = 182). In the primary analysis set (n = 318 lesions in 318 patients), recurrence occurred after 1 of 161 ESDs (0.6%) and 8 of 157 EMRs (5.1%) (relative risk, 0.12 [95% CI, 0.01 to 0.96]). No recurrence occurred in R0-resected cases (90%) after ESD. The AEs occurred more often after ESD than EMR (35.6% vs. 24.5%, respectively; relative risk, 1.4 [CI, 1.0 to 2.0]).

Limitation: Procedures were performed under general anesthesia during hospitalization in accordance with the French health system.

Conclusion: Compared with EMR, ESD reduces the 6-month recurrence rate, obviating the need for systematic early follow-up colonoscopy at the cost of more AEs.

Primary funding source: French Ministry of Health.

Publication types

  • Randomized Controlled Trial
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma* / pathology
  • Adenoma* / surgery
  • Biopsy
  • Colonic Neoplasms* / pathology
  • Colonic Neoplasms* / surgery
  • Colonoscopy / adverse effects
  • Colonoscopy / methods
  • Colorectal Neoplasms* / pathology
  • Colorectal Neoplasms* / surgery
  • Humans
  • Intestinal Mucosa / pathology
  • Intestinal Mucosa / surgery
  • Neoplasm Recurrence, Local
  • Retrospective Studies
  • Treatment Outcome

Associated data

  • ClinicalTrials.gov/NCT03962868