Pancreatic lipase and its related proteins: where are we now?

Nisha Yadav; Atish T Paul

doi:10.1016/j.drudis.2023.103855

Pancreatic lipase and its related proteins: where are we now?

Drug Discov Today. 2024 Jan;29(1):103855. doi: 10.1016/j.drudis.2023.103855. Epub 2023 Dec 9.

Authors

Nisha Yadav¹, Atish T Paul²

Affiliations

¹ Laboratory of Natural Product Chemistry, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan 333031, India.
² Laboratory of Natural Product Chemistry, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan 333031, India. Electronic address: atish.paul@pilani.bits-pilani.ac.in.

PMID: 38081381
DOI: 10.1016/j.drudis.2023.103855

Abstract

Obesity is a disease of epidemic proportions, with a worrisome upward trend. The high consumption of lipids, a major energy source, leads to obesity because of their high calorific value. Pancreatic lipase (PTL), produced by pancreatic acinar cells, hydrolyzes 50-70% of triacylglycerol (TAG) from food. PTL-related protein 1 (PLRP1) and 2 (PLRP2) are also produced by these cells. In vertebrates, PLRP1 has relatively less lipolytic activity, whereas PLRP2 has an essential role in lipid digestion, especially in infants. In this review, we summarize the structure and function of PTL, PLRP1, and PLRP2, and the metabolic fate of PTL inhibitors. We also discuss the current status of clinical trials on orlistat and its combinations for obesity treatment.

Keywords: catalytic triad; cetilistat; obesity; orlistat; pancreatic lipase.

Publication types

Review

MeSH terms

Animals
Humans
Lipase* / chemistry
Lipase* / metabolism
Obesity* / drug therapy
Obesity* / metabolism
Orlistat / metabolism
Pancreas / metabolism

Substances

Lipase
Orlistat
PNLIP protein, human
pancreatic lipase-related protein 1
pancreatic lipase related protein 2