Factors Influencing Medication Selection for Management of Overactive Bladder: Trends and Insights From AUA Quality Registry

Urology. 2024 Feb:184:51-57. doi: 10.1016/j.urology.2023.11.021. Epub 2023 Dec 9.

Abstract

Objective: To determine how a patient's demographics, including insurance type, race/ethnicity, gender, and age, may impact the choice of medication prescribed for overactive bladder (OAB).

Methods: We queried the AUA Quality Registry for adults between 2014 and 2020 with a diagnosis of OAB for >1year, excluding neurogenic causes. Variables included age, race/ethnicity, gender, insurance type, medication first prescribed, year of prescription, provider metropolitan status, and provider practice type. Primary outcome was which factors were associated with increased odds of beta-3 prescription as first medication choice.

Results: We found 1,453,566 patients with OAB, 641,122 (44.1%) with complete data. Of these, 112,021 (17.5%) were prescribed medication. On multivariate analysis, patients with Medicaid, Medicare, and other/self-pay insurance were less likely to receive a beta-3 vs an anticholinergic compared to private or military insurance. Compared to white patients, Asian, Black, and other races were less likely to receive a beta-3, as were patients outside of metropolitan areas. Age >50, prescriptions after 2014, and nonacademic settings were associated with increased odds of beta-3 prescription. There was no difference between genders.

Conclusion: Many nonclinical factors, including insurance type and race, may affect which medication is first prescribed for OAB. This is useful for practicing urologists and may help lower barriers to beta-3 prescription through policy change and advocacy.

MeSH terms

  • Adrenergic beta-3 Receptor Agonists* / therapeutic use
  • Adult
  • Aged
  • Asian
  • Black or African American
  • Female
  • Humans
  • Male
  • Medicare
  • Registries
  • United States
  • Urinary Bladder, Overactive* / drug therapy

Substances

  • Adrenergic beta-3 Receptor Agonists