Noninvasive and Multicancer Biomarkers: The Promise of LINE-1 Retrotransposons

Cancer Discov. 2023 Dec 12;13(12):2502-2504. doi: 10.1158/2159-8290.CD-23-1063.

Abstract

LINE-1 retrotransposons are frequently active in epithelial tumors. In a new study, Taylor, Wu and colleagues now describe that one of the proteins encoded by LINE-1 elements, ORF1p, is detected in the bloodstream of patients with cancer, and can be used as a noninvasive and multicancer biomarker for diagnosis or treatment monitoring. See related article by Taylor, Wu et al., p. 2532 (7).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers
  • Humans
  • Long Interspersed Nucleotide Elements
  • Neoplasms* / diagnosis
  • Neoplasms* / genetics
  • Proteins / genetics
  • Retroelements*

Substances

  • Retroelements
  • Proteins
  • Biomarkers