Primary sclerosing cholangitis and pregnancy

Obstet Gynecol. 1987 Mar;69(3 Pt 2):457-60.


Primary sclerosing cholangitis is a chronic, fibrosing, inflammatory disorder of unknown etiology affecting the biliary tree. We describe a case of a pregnancy complicated by this condition. Remarkably, maternal cholestasis improved with advancing gestation. Despite a marked elevation of bile acid levels in cord blood, the patient was delivered of a healthy term infant. The principles of management and potential effects of primary sclerosing cholangitis on pregnancy care are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bile Ducts / pathology*
  • Bile Ducts / surgery
  • Cholangitis / drug therapy
  • Cholangitis / etiology*
  • Cholangitis / surgery
  • Cholestyramine Resin / therapeutic use
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Complications / drug therapy
  • Pregnancy Complications / etiology*
  • Pregnancy Complications / surgery
  • Sclerosis


  • Cholestyramine Resin