Solid-state inorganic and metallic adhesives for soft biological tissues

Masahiro Okada; Takuya Matsumoto

doi:10.1016/j.jdsr.2023.11.003

Solid-state inorganic and metallic adhesives for soft biological tissues

Jpn Dent Sci Rev. 2023 Dec:59:439-445. doi: 10.1016/j.jdsr.2023.11.003. Epub 2023 Nov 28.

Authors

Masahiro Okada¹, Takuya Matsumoto¹

Affiliation

¹ Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.

Abstract

Currently, the soft-tissue adhesives used in clinical practice are glue-type organic adhesives. However, there is a demand for new types of adhesives, because the current organic adhesives present challenges in terms of their biocompatibility and adhesion strength. This review summarizes the discovery and development of inorganic and metallic adhesives designed for soft biological tissues while focusing on immobilization of medical divices on soft tissues. These new types of adhesives are in a solid state and adhere directly and immediately to soft tissues. Therefore, they are called "solid-state adhesives" to distinguish them from the currently used glue-type adhesives. In previous studies on inorganic solid-state adhesives, oxides and calcium phosphates were used as raw materials in the form of nanoparticles, nanoparticle-coated films, or nanoparticle-assembled porous plates. In previous studies on metallic solid-state adhesives, only Ti and its alloys were used as raw materials. This review also discusses the future perspectives in this active research area.

Keywords: Calcium phosphate; Oxide; Soft-tissue adhesive; Solid-state adhesion; Titanium.

Publication types

Review