Research progress on the mechanism of glycolysis in ovarian cancer

Chan Li; Fang-Yuan Liu; Ying Shen; Yuan Tian; Feng-Juan Han

doi:10.3389/fimmu.2023.1284853

Research progress on the mechanism of glycolysis in ovarian cancer

Front Immunol. 2023 Nov 28:14:1284853. doi: 10.3389/fimmu.2023.1284853. eCollection 2023.

Authors

Chan Li¹, Fang-Yuan Liu¹, Ying Shen^{1

2}, Yuan Tian³, Feng-Juan Han²

Affiliations

¹ Heilongjiang University of Traditional Chinese Medicine (TCM), Harbin, Heilongjiang, China.
² The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine (TCM), Harbin, Heilongjiang, China.
³ Zhejiang University of Chinese Medicine, Hangzhou, Zhejiang, China.

Abstract

Glycolysis is the preferred energy metabolism pathway in cancer cells even when the oxygen content is sufficient. Through glycolysis, cancer cells convert glucose into pyruvic acid and then lactate to rapidly produce energy and promote cancer progression. Changes in glycolysis activity play a crucial role in the biosynthesis and energy requirements of cancer cells needed to maintain growth and metastasis. This review focuses on ovarian cancer and the significance of key rate-limiting enzymes (hexokinase, phosphofructokinase, and pyruvate kinase, related signaling pathways (PI3K-AKT, Wnt, MAPK, AMPK), transcription regulators (HIF-1a), and non-coding RNA in the glycolytic pathway. Understanding the relationship between glycolysis and these different mechanisms may provide new opportunities for the future treatment of ovarian cancer.

Keywords: glycolysis; hexokinase; ovarian cancer; phosphofructokinase; pyruvate kinase.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Female
Glycolysis / genetics
Humans
Lactic Acid
Ovarian Neoplasms*
Phosphatidylinositol 3-Kinases*
Signal Transduction

Substances

Phosphatidylinositol 3-Kinases
Lactic Acid

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The work was supported by National Natural Science Foundation of China (No. 82074484), National Natural Science Foundation of China (No. 82274566), National Natural Science Foundation of China (No. 82305301).