The clinical acceptability of short versus long duration acquisitions for head and neck cancer using long-axial field-of-view PET/CT: a retrospective evaluation

Riccardo Mei; Thomas Pyka; Hasan Sari; Stefano Fanti; Ali Afshar-Oromieh; Roland Giger; Federico Caobelli; Axel Rominger; Ian Alberts

doi:10.1007/s00259-023-06516-6

The clinical acceptability of short versus long duration acquisitions for head and neck cancer using long-axial field-of-view PET/CT: a retrospective evaluation

Eur J Nucl Med Mol Imaging. 2024 Apr;51(5):1436-1443. doi: 10.1007/s00259-023-06516-6. Epub 2023 Dec 14.

Authors

Riccardo Mei^{1

2}, Thomas Pyka³, Hasan Sari^{2

4}, Stefano Fanti¹, Ali Afshar-Oromieh², Roland Giger⁵, Federico Caobelli², Axel Rominger², Ian Alberts^{2

6}

Affiliations

¹ Nuclear Medicine Department, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.
² Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstr. 18, 3010, Bern, Switzerland.
³ Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstr. 18, 3010, Bern, Switzerland. Thomas.pyka@insel.ch.
⁴ Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland.
⁵ Department of Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
⁶ Molecular Imaging and Therapy, BC Cancer Agency, Vancouver, BC, Canada.

Abstract

Purpose: To evaluate the utility of long duration (10 min) acquisitions compared to standard 4 min scans in the evaluation of head and neck cancer (HNC) using a long-axial field-of-view (LAFOV) system in 2-[18F]FDG PET/CT.

Methods: HNC patients undergoing LAFOV PET/CT were included retrospectively according to a predefined sample size calculation. For each acquisition, FDG avid lymph nodes (LN) which were highly probable or equivocal for malignancy were identified by two board certified nuclear medicine physicians in consensus. The aim of this study was to establish the clinical acceptability of short-duration (4 min, C_40%) acquisitions compared to full-count (10 min, C_100%) in terms of the detection of LN metastases in HNC. Secondary endpoints were the positive predictive value for LN status (PPV) and comparison of SUV_max at C_40% and C_100%. Histology reports or confirmatory imaging were the reference standard.

Results: A total of 1218 records were screened and target recruitment was met with n = 64 HNC patients undergoing LAFOV. Median age was 65 years (IQR: 59-73). At C_40%, a total of 387 lesions were detected (highly probable LN n = 274 and equivocal n = 113. The total number of lesions detected at C_100% acquisition was 439, of them 291 (66%) highly probable LN and 148 (34%) equivocal. Detection rate between the two acquisitions did not demonstrate any significant differences (Pearson's Chi-Square test, p = 0.792). Sensitivity, specificity, PPV, NPV and accuracy for C_40% were 83%, 44%, 55%, 76% and 36%, whilst for C_100% were 85%, 56%, 55%, 85% and 43%, respectively. The improved accuracy reached borderline significance (p = 0.057). At the ROC analysis, lower SUVmax was identified for C_100% (3.5) compared to C_40% (4.5).

Conclusion: In terms of LN detection, C_40% acquisitions showed no significant difference compared to the C_100% acquisitions. There was some improvement for lesions detection at C_100%, with a small increment in accuracy reaching borderline significance, suggestive that the higher sensitivity afforded by LAFOV might translate to improved clinical performance in some patients.

Keywords: Digital PET; Head and neck cancers; PET/CT; Positron emission tomography; Total body; Ultra-long FOV PET; Whole body.

MeSH terms

Aged
Fluorodeoxyglucose F18
Head and Neck Neoplasms* / diagnostic imaging
Humans
Positron Emission Tomography Computed Tomography* / methods
Positron-Emission Tomography
Radiopharmaceuticals
Retrospective Studies

Substances

Fluorodeoxyglucose F18
Radiopharmaceuticals