Clinical Management of Brugada Syndrome: Commentary From the Experts

Circ Arrhythm Electrophysiol. 2024 Jan;17(1):e012072. doi: 10.1161/CIRCEP.123.012072. Epub 2023 Dec 15.


Although there is consensus on the management of patients with Brugada Syndrome with high risk for sudden cardiac arrest, asymptomatic or intermediate-risk patients present clinical management challenges. This document explores the management opinions of experts throughout the world for patients with Brugada Syndrome who do not fit guideline recommendations. Four real-world clinical scenarios were presented with commentary from small expert groups for each case. All authors voted on case-specific questions to evaluate the level of consensus among the entire group in nuanced diagnostic and management decisions relevant to each case. Points of agreement, points of controversy, and gaps in knowledge are highlighted.

Keywords: Brugada Syndrome; sudden cardiac arrest; syncope; ventricular fibrillation.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brugada Syndrome* / diagnosis
  • Brugada Syndrome* / therapy
  • Consensus
  • Death, Sudden, Cardiac / etiology
  • Death, Sudden, Cardiac / prevention & control
  • Electrocardiography
  • Heart Arrest* / diagnosis
  • Heart Arrest* / therapy
  • Humans