Creatine supplementation combined with breathing exercises reduces respiratory discomfort and improves creatine status in patients with long-COVID

J Postgrad Med. 2024 Apr 1;70(2):101-104. doi: 10.4103/jpgm.jpgm_650_23. Epub 2023 Dec 7.


Eight long-COVID patients with moderate fatigue that had lasted for ≥3 months were recruited. All patients were allocated in a double-blind parallel-group design to receive either 4 g of creatine per day plus breathing exercises (study group) or breathing exercises only (control group) for 3 months. Creatine induced a significant increase in tissue total creatine levels for all 14 locations evaluated in the present study ( P < 0.05), while its levels significantly dropped in the right frontal gray matter and left parietal mesial gray matter at follow-up in the control group ( P < 0.05). No change in time to exhaustion was demonstrated in the control group (P > 0.05), while the mean time to exhaustion was significantly improved for 54 s in the study group post-administration (P = 0.05). These preliminary findings suggest that creatine is as an effective adjuvant therapeutic to breathing exercises for tackling the clinical features in long-COVID.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Breathing Exercises* / methods
  • COVID-19* / therapy
  • Creatine* / administration & dosage
  • Dietary Supplements*
  • Double-Blind Method
  • Fatigue / therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • SARS-CoV-2
  • Treatment Outcome