Long noncoding RNA: An emerging diagnostic and therapeutic target in kidney diseases

Kumaresan Ramanathan; Minale Fekadie; Giri Padmanabhan; Henok Gulilat

doi:10.1002/cbf.3901

Long noncoding RNA: An emerging diagnostic and therapeutic target in kidney diseases

Cell Biochem Funct. 2024 Jan;42(1):e3901. doi: 10.1002/cbf.3901. Epub 2023 Dec 15.

Authors

Kumaresan Ramanathan¹, Minale Fekadie¹, Giri Padmanabhan², Henok Gulilat¹

Affiliations

¹ Department of Biomedical Sciences, Faculty of Medical Sciences, Institute of Health, Jimma University, Jimma, Ethiopia.
² Kidney Care, Tiruchirappalli, India.

PMID: 38100151
DOI: 10.1002/cbf.3901

Abstract

Long noncoding RNAs (lncRNAs) have critical roles in the development of many diseases including kidney disease. An increasing number of studies have shown that lncRNAs are involved in kidney development and that their dysregulation can result in distinct disease processes, including acute kidney injury, chronic kidney disease, and renal cell carcinoma. Understanding the roles of lncRNAs in kidney disease may provide new diagnostic and therapeutic opportunities in the clinic. This review provides an overview of lncRNA characteristics, and biological function and discusses specific studies that provide insight into the function and potential application of lncRNAs in kidney disease treatment.

Keywords: AKI; CKD; RCC; kidney disease; lncRNA.

Publication types

Review

MeSH terms

Acute Kidney Injury*
Carcinoma, Renal Cell*
Humans
Kidney Neoplasms* / diagnosis
Kidney Neoplasms* / genetics
Kidney Neoplasms* / therapy
RNA, Long Noncoding* / genetics
Renal Insufficiency, Chronic* / genetics

Substances

RNA, Long Noncoding